
Pancrease is a protein mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. Contains 3 enzymes, amylase, lipase and a protease (chymotrypsin).
Pancrease is used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine.
Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malaabsorption and pain associated with pancreatic insuffiency.
The major maldigestion/malaabsorption problems arise from incomplete fat digestion.
Exogenous pancrealipase reduces the amount of nitrogen and fat excreted in the stool.
Pancrease 100comp (Janssen-Cilag)